PNLIP and obesity due to melanocortin 4 receptor deficiency: Our results showed that the majority of the tested extracts demonstrated some extent of inhibitory activity against lipase enzyme, particularly the extracts of A. nilotica and Z. spina-christi. This strongly suggests that these plants can be a source of potential leads for pancreatic lipase inhibition in order to treat and/or prevent obesity and other lifestyle-related diseases.