Microtubule structure alterations as well as alterations of binding partners necessary for proper microtubule dynamics resulting from pathogenic variants in TUBA1A, TUBB2A, TUBB2B, TUBB3, TUBB5, TUBG1 and TUBA8 genes are also responsible microcephaly and microlissencephaly. The gene discussed is TUBA1A; the disease is microcephaly.