MDA levels were higher, and SOD levels were lower in nZnO treated group (p < 0.05 for MDA and p < 0.05 for SOD) when compared with those of the control group and recovery was significant in HSP pretreated group IV as compared to nZnO treated group II (p < 0.05 for MDA and p < 0.05 for SOD). Here, SOD1 is linked to hereditary spastic paraplegia.