Similar RNA-Seq results of tilapia spleen were reported by Zhu et al. [32] that the Streptococcus iniae challenged fish were shown significantly perturbed of expression levels of C-C/C-X-C motif chemokines, C-X-C chemokines receptors, interleukins, interferons, and MHC class I/II antigens at its acute phase after infection. The gene discussed is HLA-C; the disease is infection.