PRKAA1 and cancer: In a book named “Personalized Management of Gastric Cancer”, Zhu et al. [44] demonstrated that the rs13361707 LD block mainly spans PTGER4, TTC33, and PRKAA1 gene, and a remarkable relationships between rs13361707 and these three genes were shown in the results from GTEx, so the polymorphism of rs13361707 might influence the expression of PRKAA1. In the current study, we enrolled all eligible case-control studies, from different race to different cancer types, aim to draw a systemic result for readers, and stratified analysis was also performed to avoid the bias.