According to the studies included in this review, some SNP’s investigated in the MYH9 [28], AT1R [19], and MTHFR [20] genes failed to predict prevalent CKD, ESRD or related traits (serum creatinine, eGFR and ACR), while variants in the APOL1 [27, 29, 30], apoE [21], eNOS [18, 20], XPD [22], XRCC1 [22], renalase [23, 26], ADIPOQ [31] and CCR2 [24] genes were associated with either prevalent CKD or progression of CKD, ESRD, or other surrogate measures of renal function. The gene discussed is MTHFR; the disease is chronic kidney disease.