This study found no significant effect of the Wt:G1 or Wt:G2 one-copy, but observed a high association between APOL1 two-risk alleles (G1:G1 or G1:G2 or G2:G2) and CKD (OR: 4.8; p = 5.1E-03), even after adjusting for various confounders. This evidence concerns the gene APOL1 and chronic kidney disease.