HMOX1 and Sepsis: From the previous studies, induction of HMOX1 by inflammation like in sepsis, is related both to an anti-inflammatory response and to mitochondrial biogenesis (Piantadosi et al. 2011), and HMOX1 can promote pro-inflammatory cytokine secretion and suppress inflammation-induced phenotypic maturation in the immune effector cells and enhance anti-inflammatory cytokine production (Ozen et al. 2015).