Without forgetting the activation of this cascade (TRPV-1/CGRP) during cardioprotective brief episodes (Pre-conditioning and Post-conditioning), against myocardial infarction in rat hearts [35,36], to the best of our knowledge, this study is the first to show the upregulation of the underlying pathway (TRPV-1/CGRP) using sitagliptin as a new targeting therapy in prolonged ischemia-reperfusion injury. The gene discussed is TRPV1; the disease is myocardial infarction.