Figure 5B shows that the α-Hed plus Tax combination treatment had a significantly increased rate of inhibition as compared with Tax alone. The Q value (>1.15) indicated synergy between α-Hed and Tax. Furthermore, the increased levels of cleaved poly (ADP-ribose) polymerase (PARP) and cleaved-caspase 3 expression in the NCI-H1299 cells following the combination treatment suggested that α-Hed might promote caspase-dependent cell death in chemoresistant human NSCLC cells (Figure 5C). The gene discussed is CASP3; the disease is non-small cell lung carcinoma.