A vast literature search by Skovrlj et al. yielded no evidence of BMP2 causing tumors de novo [75], although both tumor-promoting and tumor-suppressing actions of BMPs have been reported in general, dependent on the particular cellular context: BMPs seem to antagonize cancer proliferation and cancer stem cell survival, but to positively influence migration and angiogenesis [76,77]. The gene discussed is CLN5; the disease is neoplasm.