In addition, Gao et al. also enhanced the targeting property of polymeric particles by conjugating RGD and interleukin-13 peptide (IRNP), achieving the targeting of both neovasculature and cancer cells at the same time; RGD was applied for binding αvβ3 on the neovasculature, and interleukin-13 peptide targeted interleukin-13 receptor alpha 2 (IL13Rα2) on the cancer cells. This evidence concerns the gene IL13RA2 and cancer.