Alterations in cell growth pathways are seen in some pHGGs, including BRAF and FGFR1 mutations and gene fusions among the TRK family (NTRK1/2/3) (Table 1) [18]; however, BRAF/FGFR1 perturbations are far more prominent in pediatric low-grade gliomas (pLGGs) [19]. Here, NTRK1 is linked to low grade glioma.