There are ongoing studies with a number of other CDK-inhibitors that include pancreatic cancer: Ribociclib (ClinicalTrials.gov Identifier: NCT02703571; no results posted), the macrolide lactone molecule bryostatin-1 (ClinicalTrials.gov Identifier: NCT00031694; known for activation of protein kinase C, but also inhibition of CDK2 [190,255]; not effective in combination with paclitaxel in advanced pancreatic carcinoma) [256], as well as milciclib was reportedly able to overcome gemcitabine-resistance in a pancreatic cancer patients [257]. Here, CDK2 is linked to familial pancreatic carcinoma.