CCL11 and schizophrenia: Thus, decreased LTL and increased levels of C-C Motif Chemokine Ligand 11 (CCL11), which crosses the blood-brain barrier and is involved in neuroinflammation, are related with reduced grey matter volume and a longer duration of illness, consistent with the hypothesis that schizophrenia is associated with a pathological accelerated ageing, leading to impaired outcomes in these patients [146].