In addition, the risk for suicide in persons with serious mental illness, including schizophrenia, bipolar disorder, or major depression, has been shown to be associated with elevated levels of IgM antibodies to both T. gondii and CMV [127] or with elevated levels of antibodies to CMV [128] indicating that, even if these pathogens are not directly the cause of schizophrenia, they are involved in the pathogenesis, evolution, and complications of the disease. This evidence concerns the gene CD40LG and schizophrenia.