OL suppressed HFD-induced tumor growth by reducing the expression of angiogenesis (CD31, VE-cadherin, VEGF-A, and VEGFR2), lymphangiogenesis (LYVE-1, VEGF-C, VEGF-D, and VEGFR3), and hypoxia markers (HIF-1α and GLUT-1). Here, PECAM1 is linked to neoplasm.