HIF1A and neoplasm: We have contributed to demonstrate that dihydroxyphenylethanol or hydroxytyrosol (HT), a product from olive oil, blocks microsomal prostaglandin-E synthase-1 and HIF-1α dependent VEGF expression, thus reducing tumor angiogenesis [43], and promotes epidermal growth factor receptor (EGFR) degradation in colon cancer tumor cells, thus sensitizing them to anticancer drugs [44,45].