Bathia and coworkers report the antitumor effect of lycopene-enriched tomato extract (LycT) by affecting hypoxia-induced factor (HIF)-1α, VEGF, CD31, MMP-2 and MMP-9, in the initial steps of liver carcinoma chemically induced in mice, providing evidence that prophylactic dietary supplementation with LycT may counteract HCC progression and/or protect against tumor onset [40]. Here, MMP2 is linked to hepatocellular carcinoma.