As AChE inhibitors should activate the cholinergic anti-inflammatory pathway (Pavlov et al., 2003; Pavlov and Tracey, 2005; Pohanka, 2014), and PB has been shown to have anti-inflammatory effects in other illness models, such as those involving myocardial infarction and hypertension (Machado et al., 2012; Feriani et al., 2017; Bezerra et al., 2017; Feriani et al., 2018; da Silva et al., 2018), it is not surprising that PB would have a suppressive effect on cytokine expression. Here, ACHE is linked to hypertensive disorder.