Given our prior study,23 in which we identified the USP22/Wnt/β‐catenin signaling axis as a promoter of CRC stemness and chemoresistance, we investigated the impact of miR‐30‐5p expression on levels of USP22, Wnt pathway target genes, and β‐catenin in CRC cells and 5‐FU resistant CRC cells. Here, USP22 is linked to colorectal carcinoma.