PTGER3 and glioblastoma: In conclusion, our results provide the first evidence that: (a) PGE2 increases TRPM7 currents by EP3/PKA signalling pathway; (b) PGE2 potentiates TRPM7 channel currents by reducing PKA phosphorylation of S1269 site; (c) PGE2 increases TRPM7 mRNA and protein expression in human glioblastoma cells; (d) PGE2 enhances migration and proliferation of human glioblastoma cells by up‐regulation of TRPM7.