HIF1A and cancer: As HIF‐1 signalling responds to oxygen deficiency, AMPK, an energy deficiency sensor that responds to stressful environments, may play a fundamental role in cancer control and longevity.26 Therefore, we hypothesized that the MAC‐induced dysregulation of LC3‐II expression in AMPK siRNA transfected cells contributed to hypoxia‐mediated autophagy.