NR1H2 and colonic neoplasm: It was previously reported that unliganded LXRα mainly localizes the nucleus in a nuclear localization signal‐dependent manner, whereas unliganded LXRβ is partially exported from the nucleus.11, 12 In contrast, LXRβ shows predominant cytoplasmic localization in colon cancer cells but not in normal colon mucosa cells.8, 9 Both nuclear and cytoplasmic localization was observed in PDAC samples.5