NR1H3 and neurodegenerative disease: Liver X receptors (LXRs) are important members of the nuclear receptor (NR) superfamily that are involved in a number of diseases, including lipid disorders, cancer, and neurodegenerative diseases.1 Two isoforms of LXR, LXRα (NR1H3), and LXRβ (NR1H2), were initially identified as orphan receptors, and each isoform has distinct tissue expression and function.2, 3 LXRβ is ubiquitously expressed in all tissues, and there is accumulating evidence to support that LXRs are involved in a variety of cancers by different mechanisms and are potential targets in cancer therapeutics.2, 4