INS and diabetes mellitus: Recently, several studies have shown that Pknox1 was also involved in hepatic lipogenesis and insulin‐dependent glucose homeostasis.8 The Pknox1i/i mice feature a complex phenotype characterized by increased insulin sensitivity and protection from streptozotocin (STZ)‐induced diabetes, accompanied with reduced hepatic lipogenesis and protection from methionine‐ and choline‐deficient diet (MCDD)‐induced steatohepatitis.