Recently, several studies have shown that Pknox1 was also involved in hepatic lipogenesis and insulin‐dependent glucose homeostasis.8 The Pknox1i/i mice feature a complex phenotype characterized by increased insulin sensitivity and protection from streptozotocin (STZ)‐induced diabetes, accompanied with reduced hepatic lipogenesis and protection from methionine‐ and choline‐deficient diet (MCDD)‐induced steatohepatitis. The gene discussed is PKNOX1; the disease is diabetes mellitus.