Dysregulated expression of Pknox1 was shown to be associated with glucose and lipid dysmetabolism status of T2DM complicated with NAFLD.9, 19 In the rat model of STZ and HFD‐induced T2DM/NAFLD, we also found that the hepatic level of Pknox1 protein was significantly upregulated in consistent with the progression of hepatic steatosis and IR. Here, PKNOX1 is linked to Hepatic steatosis.