2018). Briefly, the animals on the HFD were significantly heavier than chow fed mice (P < 0.05) and both exercise interventions similarly prevented the weight gain (both P < 0.05). Hyperglycemia and hyperinsulinemia driven by HFD were only prevented by END (both P < 0.05). The insulin tolerance test, showed a similar blood excursion for glucose, indicating a more insulin responsive state (both P < 0.05), after END and HIIT. This evidence concerns the gene INS and hyperinsulinism.