SMO and ovarian cancer: Many studies have confirmed that the sonic hedgehog pathway is aberrantly activated in ovarian cancer.24, 25, 26 Previous findings indicate that inhibiting Hh signaling by inhibiting Smo or GLI1 results in downregulation of GLI1, consequently inhibiting cell proliferation, cell migration, cell invasion, and inducing apoptosis in ovarian cancer.25, 26, 27 This highlights that inhibition of the Hh pathway may serve as a target for the treatment of ovarian cancer.