It was reported that SM22α knockout resulted in increased atherosclerotic lesion area and a higher proportion of proliferating SMC‐derived plaque cells in animal models of atherosclerosis.29 Studies also demonstrated a decrease in transgelin expression in the synthetic VSMC induced by cytokines like TGF‐β.23 But in this study, inhibition of transgelin expression directly did not turn the hPASMC into synthetic phenotype but mainly promoted cell apoptosis. Here, TGFB1 is linked to atherosclerosis.