TAGLN and pulmonary arterial hypertension: This raised doubts on the important role of RAGE on PAH development.39 Studies in vitro reported that RAGE activation decreased the expression of transgelin on both mRNA and protein levels, and interfered with the contractile phenotype of VSMC,40 and RAGE activation‐induced apoptosis in VSMC.41 We may also consider RAGE as an important upstream regulating factor of transgelin in CHD‐PAH although the increased RAGE repression did not reach a significant level in our previous proteomics analysis.