Previous studies had shown a possible role of transgelin in hypoxic pulmonary hypertension (HPH) and pulmonary vascular remodelling under hypoxia.12, 17 In our explorative and comparative research of the lung tissue from reversible and irreversible CHD‐PAH patients and normal lung tissue, transgelin was found to be preferentially expressed in the remodelled pulmonary arterioles of CHD‐PAH patients, especially in PASMC of the pulmonary artery media from irreversible CHD‐PAH patients. The gene discussed is TAGLN; the disease is coronary artery disorder.