BCL2 and pulmonary arterial hypertension: NFATc2 activation up‐regulated bcl‐2 leading to apoptosis resistance.36, 37 Flow shear stress was reported to enhance intracellular Ca2+ signalling in PASMC from patients with PAH.38 Transgelin, as an important marker of PASMC, was closely related to pulmonary vasoconstriction and pulmonary arterial medial hypertrophy, as well as Ca2+signalling.