H19 encodes a 2.6 kb capped, spliced and polyadenylated non‐coding RNA, which is predominantly cytoplasmic.19, 20 H19 is actively involved in all stages of tumorigenesis and is expressed in multiple cancer types.21 Through inhibiting Let‐7 as a molecular sponge, H19 could sequester and regulate the suppressive Let‐7, functioning as oncogenic non‐coding gene. This evidence concerns the gene H19 and cancer.