Therefore, a recent study performed on children with obesity showed that obese girls that carry the C allele of this genotype express lower satiety responsiveness and higher uncontrolled eating scores in comparison to noncarriers, whereas, in obese boys, the carriers of the same allele present a lower rewarding value of food compared with those who do not carry the C allele Similarly, other studies performed on both adults and children showed that the expression of MC4R and FTO genes can be modulated by lifestyle and physical activity (73, 74). The gene discussed is MC4R; the disease is obesity due to melanocortin 4 receptor deficiency.