MC4R and Obesity: Therefore, a recent study performed on children with obesity showed that obese girls that carry the C allele of this genotype express lower satiety responsiveness and higher uncontrolled eating scores in comparison to noncarriers, whereas, in obese boys, the carriers of the same allele present a lower rewarding value of food compared with those who do not carry the C allele Similarly, other studies performed on both adults and children showed that the expression of MC4R and FTO genes can be modulated by lifestyle and physical activity (73, 74).