Some studies showed that FOXA2 activates lipid metabolism and ketogenesis in the liver during fasting and is inhibited by insulin‐PI3K‐Akt signaling mediated by phosphorylation at Thr156 and nuclear exclusion, not only during feeding, but also in hyperinsulinemic ob/ob or db/db mice and in animals with diet‐induced obesity 15, 29. This evidence concerns the gene AKT1 and obesity due to melanocortin 4 receptor deficiency.