Interestingly, in concordance with our in vitro H1792 cell viability MTT data (Figure 5A), selumetinib treatment alone resulted in an increased reduction of cell viability/tumor growth compared to single agent AZD2014 treatment, suggesting that this particular mutKRAS setting (KRASG12C) is more sensitive to MEK1/2 inhibition than mTORC1/2, despite RICTOR amplification. The gene discussed is MAP2K1; the disease is neoplasm.