Hepatitis B virus (HBV) infection is a prominent cause of hepatocellular carcinoma (HCC) but the underlying molecular mechanisms are complex and multiple pathways have been proposed such as the activation of the Wnt−/β-catenin-signalling and dysregulation of E-cadherin/β-catenin adherens junctions. The gene discussed is CDH1; the disease is hepatocellular carcinoma.