The adult selective downregulated gene signatures accentuate the suppressed adaptive immune pathways including T-cell cytotoxic granulysin molecule (GNLY) against TB, TCR alpha/beta or gamma delta signaling (in particular CD2, EOMES, TRA, CD8A, TRBV5-4, ZAP70, SKAP1, CD3D, TARP, FGFB2, RASGRP1, DYRK2, EVL, SH2D1A, ITK, MATK), B-cell functions (BANK1, CD19, BLK, FAM129C, MS4A1, FCRL3, EBF1, SPIB, RASGRP1, SH2D1A, FCRL2). The gene discussed is SH2D1A; the disease is tuberculosis.