ICOS and tuberculosis: Notable downregulated genes specific for childhood TB are enriched with pathways mainly involved in stimulation of T/B cells (CD40L, CD7, ICOS, FCER2, PTPRCAP, ADAM23), dendritic cell development (FLT3LG), alternative promoters of inflammation (CD248 and EDAR), and inhibition of neutrophil degranulation by ADORA3. Moreover, there is a significant suppression of IL23a that heterodimerizes with IL12B to activate the JAK-STAT-IFNG axis, and the OLIG2-SIGLEC8 eosinophil-axis is low in active but high in latent TB.