ISG15 and tuberculosis: Nevertheless, genes could be identified that were significantly upregulated only in adult TB represented an extension of the common pathways noted above associated with innate immune inflammatory response including an increased number of IFN regulated genes (PML, CXCL10, IFITM1, IRF7, OAS1, IFITM4P, ISG15, IFI35, STAT1, SOCS1, DUSP3), TLR4, TLR7/8, and TLR9 signaling cascades, and a further augmented significance for the first regulated step of the glycolytic pathway (HK3).