Furthermore, independent clinical studies have reported higher expression of TRIB1 in prostate cancer when compared to other cancers (Su et al., 2001; Ramaswamy et al., 2003) and an up-regulation of the TRIB1 gene in prostate cancer tissue when compared to adjacent cancer-free cells (Liu et al., 2006; Grasso et al., 2012). Here, TRIB1 is linked to Familial prostate cancer.