TRIB1 and Familial prostate cancer: In a previously mentioned recent study, the TRIB1 gene has also shown to play a significant role in prostate cancer, where its knockdown decreased the proliferation and survival of prostate cancer cells in a three-dimensional in vitro model, as well as it promoted prostate tumorigenesis in an in vivo xenograft model after gene over-expression (Mashima et al., 2014).