TRIB1 is also a known regulator of the mitogen-activated protein kinase (MAPK) pathway (Sung et al., 2007; Yokoyama and Nakamura, 2011), which activates/inhibits key cell processes such as growth, proliferation, differentiation, migration, and apoptosis, all of which have a pivotal role in cancer development and progression (Dhillon et al., 2007; Roberts and Der, 2007). This evidence concerns the gene WNK2 and cancer.