Although it has been previously shown that amino acid 74 in exon 2 (nucleotide position 8,563) correlates well with RA susceptibility, the extended intronic sequence information enabled us to identify in addition two positions in intron 2 correlating with RA susceptibility as well at nucleotide positions 9,139 and 9,304 of the sequence alignments using the DRB1*04 group sequences in the IPD-IMGT/HLA database after repeat sequence masking (Figure S4 in Supplementary Material). This evidence concerns the gene HLA-DRB1 and rheumatoid arthritis.