The role of this rs9277534 SNV in gene expression is important because it may provoke acute GVHD after unrelated hematopoietic cell transplantation (UR-HCT) in a different manner from the T-cell epitope (TCE) mismatching algorithm (59), reflecting exon 2 polymorphisms and structural differences of HLA-DP molecules between patient and donor and affect acute GVHD in HLA-DPB1 mismatched UR-HCT (60). Here, HLA-DPA1 is linked to graft versus host disease.