BTG3 and Infertility: A pilot case-control prospective study investigated the immune-modulating effects of short-term controlled ovarian stimulation (COS) in infertile women to assess the effects of acute increase in E2 on serum BAFF levels, Immunoglobulins, anti-nuclear antibodies (ANA) and peripheral B cell phenotype and found no significant increases in these measures of immune activation suggesting the safety of COS in infertility treatment.