While the detailed functional characterization of all X-linked miRs in autoimmunity remains to be elucidated, a number of immune-suppressive genes are targeted by X-linked miRs including Forkhead box P3 (FoxP3), cytotoxic T lymphocyte associated protein 4 (CTLA4), Casitas B-lineage Lymphoma (CBL), CBL-B, suppressors of cytokine signaling (SOCS) genes, and programmed cell death 1 (PDCD1) as evidenced by putative predicted miR target sites within their 3′UTR (37). This evidence concerns the gene PDCD1 and Autoimmunity.