Fulvestrant (Faslodex) a selective estrogen receptor downregulator and competitive inhibitor of estrogen was shown to improve SLE disease activity index (SLEDAI) scores and reduce T cell activation molecules CD154 and Calcineurin in a double-blind placebo-controlled trial in postmenopausal women with moderately active SLE (213). The gene discussed is ESR1; the disease is systemic lupus erythematosus.