The recent study by Margaroni et al. showed that vaccination with poly(D,L-lactide-co-glycolide; PLGA) nanoparticles with Leishmania infantum antigens (sLiAg) and surface-modified with a TNFα-mimicking eight-amino-acid peptide (p8) induced significant protection against parasite infection in BALB/c mice accompanied by activation of CD8+ T cells and increase in IFNγ production (223). This evidence concerns the gene CD8A and parasitic infectious disease.