Further supporting the notion that CgA and its cleavage products can be diagnostic markers for various diseases, is that elevated levels of CgA have been detected in the plasma of patients with neuroendocrine tumors (25), hypertension (99, 100) and various inflammatory diseases, such as RA (6, 101, 102), SLE (6), IBD (53, 54, 103–105) as well as T1DM and T2DM (62, 106–109). This evidence concerns the gene CGA and hypertensive disorder.