KCNQ1 and atrial fibrillation: We chose to study the V141M KCNQ1 mutation, which has been linked with multiple reports of AF (Hong et al., 2005; Villafañe et al., 2014; Righi et al., 2016), and use the V307L KCNQ1 mutation as a comparator, which has distinct kinetics and has been demonstrated to promote ventricular arrhythmogenesis in our previous computational modelling study (Adeniran et al., 2017).