In terms of the CaMKII site evidence suggests a progression from the earliest effects of signal silencing in which RyR phosphorylation decreases (Greiser et al., 2014), to the majority of papers in paroxysmal AF reporting an increase in RyR phosphorylation (Chelu et al., 2009; Greiser et al., 2009; Chiang et al., 2014b). The gene discussed is CAMK2G; the disease is Paroxysmal atrial fibrillation.