This cytokine induces a protective and anti-tumor response in CRC patients (Evans et al., 2006; Kantola et al., 2012; Ganapathi et al., 2014); accordingly, reduced expression of IFN-γ in peripheral blood mononuclear cells of CRC patients could contribute to CRC progression and recurrence (Ganapathi et al., 2014). Here, IFNG is linked to colorectal carcinoma.