An active interplay has been demonstrated to go on between these same cytokines, as interleukins (i.e., IL-1b, IL-6, IL-17, IL-15), TNFα, and interferon gamma (IFN-γ), and conventional chemotherapeutics, including 5-FU and OXA, eventually affecting the overall therapeutic outcome in patients undergoing anti-tumor treatments (Tesniere et al., 2010; Vincent et al., 2010; Apetoh et al., 2011; Cressman et al., 2012; De Mattia et al., 2013, 2018; Ni et al., 2013; Ghiringhelli and Apetoh, 2014; Guo et al., 2014; Wang et al., 2016; Wu et al., 2016; Hu et al., 2018). Here, IFNG is linked to neoplasm.