A multiparametric score of DFS integrating the genetic MTHFR-rs1801131 marker with clinical factors (i.e., gender, primary tumor site, and tumor stage) was previously developed, where the MTHFR-rs1801131-CC genotype (vs. rs1801131-AA/AC genotype), male sex (vs. female), colon primary tumor site (vs. rectum), and tumor stage III (vs. stage II) were considered negative prognostic factors for DFS (Cecchin et al., 2015). The gene discussed is MTHFR; the disease is neoplasm.