Other in vitro and in vivo data (Patras et al., 2016; Malesci et al., 2017) further indicated there was an interplay between 5-FU and the TAMs, another class of immune cells whose activity is partially regulated by IFN-γ (Poh and Ernst, 2018), in determining CRC cell death and the efficacy of adjuvant 5-FU-based therapy. This evidence concerns the gene IFNG and colorectal carcinoma.