Similarly, oesophageal squamous cell carcinoma (ESCA) and cervical squamous cell carcinoma (CESC) data sets from TCGA showed a similar trend, with a significant decrease (p-value: 4.1 × 10−1–2.6 × 10−4) of ZNF185 expression in the high-grade tumours with respect to the low-grade tumours in both types of carcinomas (Fig. 5d). The gene discussed is ZNF185; the disease is carcinoma.