To provide a more detailed analysis of the reduced β-catenin transcriptional activity with progerin expression and also in the presence of lamin A expression, since this is what is happening in the HGPS patients, we transfected the G608G lamin A (that express both progerin and lamin A) and the Δ50 lamin A (that only express progerin) expression vectors. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.