Then, we found that SDF-1-induced SATB-1 upregulation inhibits proliferation, migration, and invasion of pancreatic cancer cells, and conditioned medium from SW1990 and PANC-1 cells expressing SATB-1 maintains the properties of older CAFs, forming a SATB-1-centered positive feedback loop. The gene discussed is SATB1; the disease is familial pancreatic carcinoma.