Collin et al. (2009) [16] investigated the effect of eight SNPs, including MTHFR rs1801133, MTHFR rs1801131, METH rs1805087, METHR rs1801394, MTHFD1 rs2236225, SLC19A1/RFC1 rs1051266, SHMT1 rs1979277, and FOLH1 rs202676, on PCa risk in a meta-analysis and found no significant effects of any of these SNPs on PCa susceptibility. This evidence concerns the gene MTHFD1 and posterior cortical atrophy.