In a reciprocal approach, depletion of SGK1 in T47D and MDA-MB-231 cells led to a decrease in expression of NDRG1 (Fig. 4A) with an inverse effect observed on migration and invasion of the breast cancer cells (Fig. 4, B and C), regardless of progesterone treatment (Fig. 5, A and B). The gene discussed is NDRG1; the disease is breast carcinoma.