Furthermore, consistent with the genetic perturbation, pharmacological inhibition of SGK1 with 1 μm GSK650394A similarly blocked the effect of progesterone on breast cancer cell migration and cell invasion, suggesting an essential role of the SGK1/NDRG1 axis downstream to progesterone in breast cancer cells independent of their hormonal receptor status (Fig. 6). The gene discussed is NR4A1; the disease is breast cancer.