SGK1, when overexpressed in PR-positive T47D and PR-negative MDA-MB-231 breast cancer cells, mimicked the effect of progesterone by up-regulating the expression of NDRG1 (Fig. 3A), which in turn led to a significant reduction in cell migration and cell invasion (Fig. 3, B and C). The gene discussed is PGR; the disease is breast carcinoma.