CircMOT1 sponges miR-9 to suppress HCC progression [13], circMYLK sponges miR-29a to activate the VEGFA/VEGFR2 pathway to promote bladder cancer progression [16], and ciRS-7 is involved in a variety of cancers by its interaction with miR-7 [33]. This evidence concerns the gene KDR and hepatocellular carcinoma.