GH1 and acromegaly: To study the effect of GH excess on DNA damage, we retrieved differentially expressed genes (DEGs) between WT and acromegaly zebrafish (one-year-old) following RNA-Seq analysis from different organs and assessed the X2K subnetwork [14] of upregulated genes in the liver, kidney, brain, and larvae to determine the main kinase and transcription factors driving the expression of DEGs.