After adjustment for demographics, smoking history, family history of T2DM, and medication status (Model 1), reallocating 30 min from sleep, sitting, or standing to stepping resulted in favourable associations for 2-h glucose (−5 fold [sleep], −4 fold [sitting], −5 fold [standing]), 2-h insulin (−17 fold, −15 fold, −15 fold), HOMA-IS (13 fold, 13 fold, 12 fold), and Matsuda-ISI (12 fold, 10 fold, 9 fold). This evidence concerns the gene INS and type 2 diabetes mellitus.