For example, SEA-induced Tregs play a role in preventing T1D in NOD mice [15], H. polygrus-induced Tregs [32] represent one of the major mechanisms by which this worm is able to prevent colitis in mouse models [33] and infection of mice with F. hepatica elicits a (modest) increase in FoxP3+ T cells in the pleural cavity, which is associated with increased IL-10 and protection against EAE [19]. Here, FOXP3 is linked to colitis.