In MS models, unlike in the NOD mouse where disease develops spontaneously, EAE is generated following immunisation with myelin oligodendrocyte glycoprotein (MOG) or myelin basic protein (MBP) in Complete Freunds Adjuvant (CFA) to induce a potent Th1/17 autoimmune response. The gene discussed is MBP; the disease is myeloid sarcoma.