Interestingly, irrespective of the means (exercise, heat shock therapy, transgenic overexpression, or pharmacologic agents) used to elevate the expression of HspA1A (Hsp72), protection against diet- or obesity-induced hyperglycemia, hyperinsulinemia, glucose intolerance, and insulin resistance still appears to be maintained [45,46]. This evidence concerns the gene HSPA1A and hyperinsulinism.