Research on the involvement of chaperones in the pathogenesis of type 2 diabetes mellitus has documented the role of HspA1A (Hsp72) in the prevention of β-cell mass decline, suppression of inflammation, and attenuation of insulin resistance, especially in the context of obesity or a high-fat diet [45]. This evidence concerns the gene HSPA1A and obesity due to melanocortin 4 receptor deficiency.