In addition, insulin levels were found to be correlated with LNM risk in both premenopausal and postmenopausal women with endometrial cancer.42 In view of these findings, it is suggested that IGF1 rs5742612 A > G polymorphism may increase insulin secretion and induce lymphangiogenesis and facilitates lymphatic metastasis. Here, IGF1 is linked to endometrial cancer.