We next examined genomic copy number of FOXJ2 in tumor tissues and corresponding peritumoral tissues from 9 HCC patients, which showed that HCC tumor tissues had much lower genomic copy number of FOXJ2 than paired peritumoral tissues (Fig 4J), suggesting that decreased FOXJ2 expression is at least partially due to such low genomic copy number. Here, FOXJ2 is linked to neoplasm.